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μCollaFibR™ Additive for Bioinks and Hydrogels
$240.00 – $530.00
*Please note all prices are in US Dollars.
μCollaFibR™ Additives for Bioinks and Hydrogels – 3D Bioprinting is a promising approach for personalized tissue engineering, but the lack of mechanical durability and biological relevance of bioprinted constructs has limited their clinical viability. 3D BioFibR’s patented dry-spinning technology produces μCollaFibR™; 50 μm collagen fibers that increase the shape fidelity and biological relevance of bioprinted constructs. With excellent chemical stability and 1-2 μm diameters, μCollaFibR™ is universally compatible with bioprinting materials and modalities.
- Produced using GMP type I collagen, and resembles the structure of natural collagen fibers
- Can be resuspended in any aqueous environment, including acidic environments (pH≥2)
- Increases mechanical strength and modulus of hydrogels in extension and compression
- Improves shape retention/durability for at least 28 days in cellular constructs
- Acts as a physiologically relevant site for cell attachment within the constructs, improving cellular viability and functionality
- Improves shape fidelity without compromising bioink viscosity/printability
Safety Data Sheet
Features
Biocompatible
It has a much lower antigenicity compared to similar collagen-based bioinks because of its arginine-glycine-aspartic acid (RGD) peptide sequence. This tripeptide sequence promotes cellular growth increasing cellular viability when cells are incorporated.
Biodegradable
GelMA contains matrix metalloproteinase (MMP) degradable motifs which are enzyme binding locations that trigger the catabolism of the gelatin architecture in GelMA. The degradation of GelMA is then replaced by the natural ECM without triggering a severe inflammatory response.
Naturally Derived
GelMA contains a gelatin protein base derived from naturally occurring sources.
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